What is DHEA-S(Dehydroepiandrosterone sulfate)?

Dehydroepiandrosterone sulfate (DHEA-S) is a sulfated form of the hormone dehydroepiandrosterone (DHEA). DHEA-S is the most abundant circulating form of DHEA in the bloodstream. Like DHEA, it is produced primarily by the adrenal glands, which are located on top of the kidneys.

Key Points about DHEA-S:

• Production: DHEA-S is synthesized in the adrenal glands, primarily from DHEA. It is released into the bloodstream and circulates throughout the body.
• Sulfation Process: DHEA is converted to DHEA-S through a process called sulfation. Sulfation involves adding a sulfate group to the DHEA molecule, which increases its stability and water solubility.
• Circulating Form: DHEA-S is the major circulating form of DHEA in the bloodstream. It is present in much higher concentrations than free, unconjugated DHEA.
• Diagnostic Marker: DHEA-S levels can be measured in blood tests to assess adrenal gland function and as an indicator of overall DHEA levels in the body. Abnormal levels of DHEA-S may provide insight into certain adrenal disorders or hormonal imbalances.
• Clinical Applications: While DHEA-S is primarily used as a marker of adrenal function, its clinical applications are limited compared to DHEA. DHEA-S supplementation is not commonly recommended or prescribed, as the sulfated form is less biologically active than DHEA.

Difference Between DHEA and DHEA-S: DHEA (Dehydroepiandrosterone) and DHEA-S (Dehydroepiandrosterone sulfate) are both hormones that are produced by the adrenal glands. They are precursors to hormones such as estrogen and testosterone and play various roles in the body. However, there are some key differences between DHEA and DHEA-S.