Blood Coagulation

Blood Coagulation/ Clotting

The most prevalent fluid in our bodies is blood, which circulates under intense pressure throughout the body and keeps it working. Significant blood loss can occasionally result in death....

Difference

Extrinsic and intrinsic are the two main routes by which blood clots. When blood contacts damage the vessel wall, the extrinsic channel is opened up. When blood interacts with an alien substance like a virus or bacteria, the intrinsic route is set off. The production of a fibrin clot is the end result of both paths. But there are also significant variations between the two routes. Faster than the intrinsic pathway is the extrinsic pathway. This is so because the extrinsic pathway uses already-formed components that are found in the blood. The intrinsic process, in contrast, necessitates the creation of fresh clotting components. As a result, the intrinsic pathway produces clots more slowly. Larger wound closure is also more successful using the extrinsic pathway. This is so that the extrinsic process, as opposed to the intrinsic pathway, creates a stronger clot. However, because the intrinsic pathway results in a more confined clot, it is more efficient at closing off tiny wounds. Both pathways are crucial for blood clotting in the end. The size and location of the incision determine which pathway....

Treatment Implications

Treatment options may be affected by the distinction between intrinsic and extrinsic clotting pathways. For instance, medications that target factor VIIa, a protein involved in the extrinsic route, are used to treat hemophilia A and B. Von Willebrand disease is treated with factor VIII inhibitors, a protein involved in the extrinsic route....

Process of Blood Coagulation

The mechanism by using which the body stops bleeding to forestall regular loss of blood is recognized as hemostasis. The entire process is divided here into three predominant steps:...

FAQs on Blood Coagulation

Question 1: What is a coagulation test?...