Clinical Application of Genetic Linkage
- Enables the discovery of marker genes connected to severe dominant diseases.
- Genetic linkage improves the prediction of the disease’s distribution in short-family pedigrees.
- A genetic marker would typically be a collection of alleles at a locus that is tightly linked to the specific illness gene; the closer the link, the better the marker because there is less uncertainty caused by potential gene crossover between the marker and disease genes.
- Genetic linkage does not mean that a particular allele is connected to the disease in general.
Genetic Linkage
The tendency of genes on a chromosome to stick together during chromosomal inheritance is known as linkage. Contrarily, crossing over is the process through which genetic material from homologous chromosomes is exchanged to create a new gene combination. Linkage creates parental types and aids in the preservation of a better new variety.
Significance of Linkage
- For upcoming generations, it helps in restoring the paternal genes
- It’s important to preserve a newly developed variety’s positive trait
- It is essential for determining a plant’s capacity for hybridization.
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