What is Major Histocompatibility Complex (MHC)?
Major Histocompatibility Complex (MHC) are the substances that are present on the surface of the nucleated cells. They are made with proteins. In the human body, there are nearly every cell has the Major Histocompatibility Complex (MHC) on its cell surface. Only, the Neurons don’t have such cells. As there is no nucleus present inside any neurons. The Major Histocompatibility Complex (MHC) is located inside the cells. But whenever there is a problem related to the Immune System of the body, it comes to the surface of the cell to do a task.
Major Histocompatibility Complex (MHC) identifies the foreign substances that are a potential threat to the body. There may be two types of foreign substances. One is linked with the body component & another is completely different from the body component. Word “Histo” means the tissues and the word “Compatibility” means living with harmony. A combination of these two words created Major Histocompatibility Complex (MHC).
Major Histocompatibility Complex (MHC) works with the T Lymphocytes. Major Histocompatibility Complex (MHC) only provides the signal of the foreign elements. The foreign element is going to be destroyed by the T lymphocytes. As per the type of the Major Histocompatibility Complex (MHC), the T lymphocytes also altered.
Discovery Of Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC) was first discovered by the immunologist Peter Gorer in the 1930s. this was first discovered during the transplantation of the tissues. Peter Gorer was experimenting with the mice. He was trying to transplant tissues from one mouse to another mouse. Tissue transplantation is a process where a group of cells or tissue is injected or transplanted into another creature. Organ transplantation is the higher form of this experiment.
But during this experiment, Peter Gorer visualize something abnormal. He find out that, the mice on which the tissue was transplanted died some days. So, he decided to change the path of the experiment. He took a group of mice. And he makes a tissue transplant on both those groups. Both groups are different mice species. One group acts the same as the previous. One group eventually died. And another group survives.
After this experiment, he comes to the conclusion that there is something in the tissues that act as a foreign element for some mice. And for other mice, don’t have any such problems. Later, it is discovered that the substances that are destroying the mice are the MHCs. The MHCs also present in humans. That is why it is very crucial to check all the parameters before going for organ transplantation.
Major Histocompatibility Complex(MHC)
The immune system is the most essential system of our body. It not only helps to protect the creature from foreign substances. Also, it helps to grow up without any outside disturbance. The immune system protects us from various threats. It protects from various foreign substances. It identifies them & destroys them. so, that the animal can able to grow up without any issues. Sometimes it is assumed that Immune System is only made with the White Blood Corpuscles. But that is not a correct assumption. It is a complete system where different components & proteins play an important role. Major Histocompatibility complexes (MHC) are similar kinds of a substance.
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