Senescent Cells
Senescent cells are cells that have stopped dividing but remain alive and release chemicals that can cause inflammation. They are also known as “zombie cells” because they refuse to die easily. Senescent cells have a flattened and enlarged appearance. They have molecular markers like lipofuscin granules, DNA scars, and altered gene expression. Senescent cells undergo phenotypic changes, including:
- Chromatin changes
- Secretome changes
- Tumor-suppressor activation
Over time, large numbers of senescent cells can build up in the body’s tissues. The accumulation of these cells can impair intercellular communication and compromise tissue function. This can lead to inflammation, cell death, and loss of cardiomyocytes. Senescent cells secrete a variety of extracellular modulators, including: Cytokines, Chemokines, Proteases, Growth factors, Bioactive lipids.
The secretion of these modulators is known as the senescence-associated secretory phenotype (SASP). The SASP can affect the surrounding cells and contribute to cancer and the aging process. Senescent cells can alter the local tissue environment and contribute to chronic inflammation and cancer. Senolytics are drugs that can eliminate senescent cells.
What is Senescence? – Senescent Cells And Senescence In Plants
Senescence is the process by which cells stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence cells get old and weaken, causing a decline in tissue function and decay. Senescence in plants is a programmed death of leaves as part of developmental cycles. In animals, senescent cells contribute to aging and age-related diseases.
Senescence can be induced by unrepaired DNA damage or other cellular stresses. It plays a role in normal development, maintains tissue homeostasis, and limits tumor progression. In this article, we will read about what is senescence, its causes, and effects, senescent cells, the different types of senescence in plants, theories of aging, factors affecting senescence, and its importance.
Table of Content
- Senescence Definition
- Senescence Meaning
- Senescent Cells
- Causes of Senescence
- Types of Senescence
- Theories of Aging
- Effects of Senescence
- Factors that Influence the Senescence in Plants
- Importance of Senescence
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