Major Histocompatibility Complex (MHC) Class II
- These are the molecules that are present in the antigen-representing cells. This means those cells which are primarily responsible for destroying foreign substances.
- It completely binds with the exogenous cells. This means those cells that completely come from the outside of the body
- It only binds with the T Helper (Th) cells. This type of T lymphocyte can only recognize the response of the MHC Class II.
- There is only one type of gene present inside the MHC class II. They are the simple HLA.
- The size of the MHC Class II cells depends upon the chain type. As per the chain type, the size will get changed.
- It can only able to get outside of the cell when the foreign element is inside the cell body.
Structure Of The Major Histocompatibility Complex (MHC) Class II
There are mainly two types of chains. There is an Alpha & Beta chain. But the structure is different from the structure of Class I. Here, two chains are anchored inside the cell membrane. Both chains have one side inside of the cell membrane. The other side makes the structure. There are two different changes. And those chains make different domains.
The Alpha chain will create two domains. They are the Alpha1 & Alpha2. The Beta chain will also make two different domains. One is Beta1 & another is Beta2. All the chains will attach by non-covalent bonds. There are di-sulfate bonds in the domain. Except for the Alpha2 domain, in every domain, there is the di-sulfate bond. This bond will help to hold the domain to its structure. The Alpha1 & Beta1 will jointly make the peptide bonding place. This is the place where the foreign substance will get attached. As a result, the signal will go to the T Helper cells to destroy the substances.
Major Histocompatibility Complex(MHC)
The immune system is the most essential system of our body. It not only helps to protect the creature from foreign substances. Also, it helps to grow up without any outside disturbance. The immune system protects us from various threats. It protects from various foreign substances. It identifies them & destroys them. so, that the animal can able to grow up without any issues. Sometimes it is assumed that Immune System is only made with the White Blood Corpuscles. But that is not a correct assumption. It is a complete system where different components & proteins play an important role. Major Histocompatibility complexes (MHC) are similar kinds of a substance.
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