Coenzyme vs Cofactor – Difference Between Coenzyme and Cofactor

The difference between coenzyme and cofactor is given below in the tabular form:

Feature

Coenzyme

Cofactor

Other Names

Coenzyme is additionally referred to as a Co-substrate and secondary substrate.

A cofactor is additionally referred to as a helper molecule or an accessory molecule.

Chemical Nature

Coenzymes are the organic molecule

Both organic and inorganic substances could serve as cofactors.

Types

Coenzyme is a type of cofactor

Both coenzyme and prosthetic groups are two types of cofactors.

Binding

They are loosely bound with an enzyme

They are tightly bound with an enzyme

Role

Coenzymes act as carriers and molecule substrates to the enzymes.

Cofactors increase the rate of the reaction that is catalyzed by the relevant enzyme

Separation

Coenzyme substrate easily separate because they are loosely bound to an enzyme

Cofactor molecules are tightly bound with the enzyme and are not possible to remove without denaturation

Example

NAD, NADP, etc.

Metal ions like Zinc, Copper, Cobalt, Molybdenum, etc.

Difference Between Cofactor And Coenzyme

The difference between cofactor and coenzyme lies in their composition and role in enzymatic reactions. While cofactors can be either inorganic ions or organic molecules, coenzymes are specifically organic molecules that assist enzymes by carrying chemical groups or electrons.

In this article, we will cover the difference between cofactors and co-enzymes.

Difference Between Cofactor And Coenzyme

Table of Content

  • Coenzyme Meaning
  • Cofactor Meaning
  • Coenzyme vs Cofactor – Difference Between Coenzyme and Cofactor
  • Similarities Between Cofactor And Coenzyme
  • Conclusion – Difference Between Cofactor And Coenzyme
  • Other Related Articles on Differences
  • FAQs on the Difference Between Cofactor And Coenzyme

Similar Reads

Coenzyme Meaning

Coenzymes are organic molecules that act as cofactors with enzymes, supporting their function. These small, non-protein molecules are present in cells and serve as carriers for electrons or functional groups during catalysis. For instance, electrons participate in NAD-coupled oxidation-reduction reactions. Coenzymes change throughout the process and need a different enzyme to return to their original form, thus being referred to as co-substrates or secondary substrates....

Cofactor Meaning

A cofactor is a non-protein chemical substance that binds firmly to an enzyme, helping its function. Cofactor associates with an inactive enzyme, called an apoenzyme, to form an active enzyme, or holoenzyme. Cofactors can be inorganic (metal ions) or organic (coenzymes and prosthetic groups)....

Coenzyme vs Cofactor – Difference Between Coenzyme and Cofactor

The difference between coenzyme and cofactor is given below in the tabular form:...

Similarities Between Cofactor And Coenzyme

Despite the difference between cofactor and coenzyme, the similarities between cofactor and coenzyme:...

Conclusion – Difference Between Cofactor And Coenzyme

The difference between coenzyme and cofactor is delineated in the tabular form, highlighting their distinct characteristics. Coenzymes, also known as co-substrates or secondary substrates, are organic molecules that support enzyme function, while cofactors, termed helper molecules or accessory molecules, can be both organic and inorganic substances. Despite their differences, both play vital roles in enzyme-mediated reactions and are crucial for metabolic pathways within cells....

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FAQs on the Difference Between Cofactor And Coenzyme

How is a Cofactor Different from a Coenzyme?...

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