Cell-matrix interaction

Cell-matrix interactions are mediated by adhesion receptors and result in the creation of multi-protein adhesion structures that interact with the actin cytoskeleton at the interior of the cell (CMACs). They are collectively known as cell-matrix adhesion complexes.

These adhesions serve as crucial data processing hubs that allow cells to detect a variety of extracellular signals that contain details on the chemical, geometry, and physical characteristics of the ECM. Mechanosensitive cells communicate this information to subsequent mechanotransduction pathways and signalling cascades to affect a variety of processes, including the cell shape, polarity, fate, motility, and the deposition and/or restructuring of ECM components. The substrate type or chemical composition, its rigidity, and its surface topography influence force-induced events through CMACs.

Cell Junctions

 

Anchoring junctions and tight junctions are the other two types of cell junctions seen in vertebrates. Through proteins attached to the cytoskeleton of the cell, anchoring junctions hold cells together. Epithelial cells, which are cells found on the surface of the body and lining organs, frequently have tight junctions, which are regions where cells are joined very closely together to form a barrier.

While plant cells lack gap junctions, they do have plasmodesmata, which act as conduits to connect the cytoplasm of two nearby plant cells. Plasmodesmata have a different structure than gap junctions because plant cells have strong cell walls, but they serve roughly the same purpose. Through their plasmodesmata, plant cells may communicate with one another and control the movement of tiny chemicals.

Gap Junction

The fundamental structural and operational unit of all living things is the cell. Each cell has a cytoplasm that is surrounded by a membrane and is home to a variety of biomolecules, including proteins and nucleic acids.

Cells can develop specialised functions and perform a variety of tasks within the cell, including protein synthesis, DNA repair, replication, and motility. Within the cell, cells can specialise and move around. Due to their small size, the majority of cells are measured in micrometres.

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Cell-cell Interaction

The term “cell-cell interaction” describes the physical contact between cell surfaces, which is essential for the growth and operation of multicellular organisms. Cells can communicate with one another through these interactions to react to changes in their surroundings. The cell’s survival depends on its capacity to transmit and receive messages. Stable cell-cell interactions, such as those made through cell junctions, are possible. These junctions let cells within a particular tissue communicate and organise themselves. Others, including those between immune system cells or the connections that cause tissue inflammation, are transitory or short-lived. These interactions between cells are different from others, such as those between cells and the extracellular matrix. Cancer and unregulated cell proliferation may originate from a breakdown in cell communication....

Cell-matrix interaction

Cell-matrix interactions are mediated by adhesion receptors and result in the creation of multi-protein adhesion structures that interact with the actin cytoskeleton at the interior of the cell (CMACs). They are collectively known as cell-matrix adhesion complexes....

Gap Junction

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Gap Junction Structure

Connexin proteins make up gap junctions in the cells of vertebrates. (Gap junctions in invertebrate cells are made up of innexin proteins, which are unrelated to connexin proteins but serve a similar purpose.) A connexon is made up of six connexin groups, and two connexons combined make a channel through which molecules can move. Pannexin proteins make up additional channels in gap junctions. Pannexins were first believed to only create channels within a cell, not across cells, hence they are still relatively poorly understood. In what is referred to as a gap junction plaque, hundreds of channels are discovered together at the location of a gap junction. A mass of proteins makes up a plaque...

Specialised Function Revealed by Connexin Mutation

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FAQs on Gap Junction

Question 1: What is Gap Junction?...

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