Causes of Senescence
Senescence can be caused by a number of factors, including:
- DNA Damage: Accumulation of DNA damage over time can trigger cellular senescence. It leads to a halt in cell division and altered cellular function.
- Telomere Shortening: As cells divide, the protective caps on the ends of chromosomes, called telomeres, gradually shorten and once they reach a critical length, cells enter senescence.
- Oxidative Stress: Increased levels of reactive oxygen species (ROS) from metabolic processes can damage cellular components and contributes to senescence.
- Mitochondrial Dysfunction: Mitochondrial function that are responsible for energy production decreases which disrupts cellular homeostasis and lead to senescence.
- Genetic Factors: Certain genetic factors and regulatory pathways can predispose cells to enter a senescent state.
- Inflammatory Signals: Chronic inflammation, either due to external factors or the senescence-associated secretory phenotype (SASP), can induce senescence in neighboring cells.
- Environmental Stressors: Exposure to environmental stressors such as toxins, radiation, and pollutants can accelerate the onset of senescence.
Also Read: Mitochondria
What is Senescence? – Senescent Cells And Senescence In Plants
Senescence is the process by which cells stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence cells get old and weaken, causing a decline in tissue function and decay. Senescence in plants is a programmed death of leaves as part of developmental cycles. In animals, senescent cells contribute to aging and age-related diseases.
Senescence can be induced by unrepaired DNA damage or other cellular stresses. It plays a role in normal development, maintains tissue homeostasis, and limits tumor progression. In this article, we will read about what is senescence, its causes, and effects, senescent cells, the different types of senescence in plants, theories of aging, factors affecting senescence, and its importance.
Table of Content
- Senescence Definition
- Senescence Meaning
- Senescent Cells
- Causes of Senescence
- Types of Senescence
- Theories of Aging
- Effects of Senescence
- Factors that Influence the Senescence in Plants
- Importance of Senescence
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