Causes of Cushing Syndrome
- Iatrogenic factors, such as the prolonged use of glucocorticoids
- Pituitary adenomas: The disorder is known as Cushing’s disease when the clinical symptoms are caused by a pituitary adenoma.
- Cancers such small cell lung carcinomas, adrenal carcinomas, and bronchial carcinomas.
- Adrenal tumors.
- Macronodular hyperplasia without ACTH.
- Alcoholism and depressive disorders.
- Initial obesity.
Difference Between Addison’s Disease and Cushing’s Syndrome
The main distinction between Addison syndrome and Cushing’s disease is that Cushing’s syndrome exhibits an excess of cortisol while Addison’s disease exhibits a hormonal deficiency of cortisol and aldosterone. To correctly diagnose and treat Addison’s disease and Cushing’s syndrome, it’s critical to understand their differences. The hypofunction of the adrenal gland, which may be brought on by primary adrenocortical insufficiency or a lack of pituitary adrenocorticotropic hormone (ACTH) release, is the underlying cause of Addison’s disease. On the other hand, overproduction of the hormone cortisol in the body results in Cushing’s syndrome. Let’s have a glance at both topics in detail.
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