Agranulocytes

Agranulocytes are white blood cells that have no granules. They present one nucleus that’s why they are known as mononuclear leukocytes. They have larger nuclei due absence of unnoticeable granules. 

Three types of Agranulocytes are: 

Monocytes

• They present large numbers.
• They have large nucleus structures and kidney-shaped structures ( Sometimes called amoeboid structures).
• Monocyte develops macrophages and dendritic cells.
• It activates an inflammatory reaction.
• It can activate adaptive immune responses.
• Monocytes release cytokines and chemokines.

Types of monocytes

• Macrophage
  • Present in almost all tissue.
  • They actively perform phagocytic functions.
• Dendritic Cells
  • Act as the neurotransmitter connects with external antigens.
  • Their primary function is to provide the presence of antigens to lymphocytes.
  • They are unicellular, and their projection same as dendrites.

Lymphocytes

• Most commonly found in the cytoplasm after neutrophils.
• Spherical in shape.
• They have a very large nucleus with low cytoplasm.
• The main types of lymphocytes- are T-cell, B-cell, and Natural killer cells.
• They are natural killer cells.

The first line of defense in the human body is WBCs which are also known as leukocytes are the cells of the immune system. It circulates throughout the blood and lymphatic system. Leukocyte plays important role in the immune system by identifying, destroying, and removing pathogens and damaged cells. These cells can leave blood cells and migrate through body fluids. Leukocytes originate in the bone marrow and circulate in lymph nodes.  Leukocytes can be characterized by the presence and absence of granules (Sacs containing digestive enzymes or other chemical substances) in the cytoplasm. If there is the presence of granules are granulocytes and if there absence of granules they are called agranulocytes.  Granulocytes include Eosinophile, Neutrophiles, and basophils. Agranulocytes are monocytes and lymphocytes.